I eventually found out that by stopping the Cisco An圜onnect Secure Mobility Agent service or the Sophos Anti-Virus service, the database will successfully update but obviously this isn't suitable. We only have a few users with cisco anyconnect installed and they are the only ones affected by this, it also happens when they are in head office connected to our network. Hi all, we are having an ongoing issue where every so often sophos fails to update the database on clients pc's whether they are connected to the VPN or not.
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